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Tetsuo Takehara Selected Research

Chronic Hepatitis (Chronic Active Hepatitis)

10/2021Treatment progress and expansion in Japan: From interferon to direct-acting antiviral.
6/2012N-Acetylglucosaminyltransferase V regulates TGF-β response in hepatic stellate cells and the progression of steatohepatitis.
5/2012Long-term effect of lamivudine treatment on the incidence of hepatocellular carcinoma in patients with hepatitis B virus infection.
1/2012Fibroblast growth factor-2 enhances NK sensitivity of hepatocellular carcinoma cells.
3/2010Fatal exacerbation of type B chronic hepatitis triggered by changes in relaxed circular viral DNA synthesis and virion secretion.
1/2010Guidelines for the treatment of chronic hepatitis and cirrhosis due to hepatitis B virus infection for the fiscal year 2008 in Japan.
5/2009Effect of interferon alpha-2b plus ribavirin therapy on incidence of hepatocellular carcinoma in patients with chronic hepatitis.
5/2009Mutations associated with the therapeutic efficacy of adefovir dipivoxil added to lamivudine in patients resistant to lamivudine with type B chronic hepatitis.
1/2009Lamivudine-to-entecavir switching treatment in type B chronic hepatitis patients without evidence of lamivudine resistance.
10/2008Supportive role played by precore and preS2 genomic changes in the establishment of lamivudine-resistant hepatitis B virus.

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Tetsuo Takehara Research Topics

Disease

68Hepatocellular Carcinoma (Hepatoma)
12/2022 - 04/2003
67Neoplasms (Cancer)
12/2022 - 04/2003
57Chronic Hepatitis C
10/2022 - 02/2003
43Infections
10/2022 - 02/2003
33Fibrosis (Cirrhosis)
10/2022 - 01/2010
30Liver Cirrhosis (Hepatic Cirrhosis)
10/2022 - 10/2004
20Inflammation (Inflammations)
11/2021 - 02/2010
16Non-alcoholic Fatty Liver Disease
11/2021 - 01/2013
13Inflammatory Bowel Diseases (Inflammatory Bowel Disease)
01/2022 - 05/2012
13Liver Diseases (Liver Disease)
01/2022 - 07/2006
12Hemorrhage
05/2022 - 01/2013
12Crohn Disease (Crohn's Disease)
07/2021 - 05/2012
11Colitis
12/2020 - 05/2012
11Hepatitis C
10/2020 - 01/2009
10Carcinogenesis
01/2022 - 01/2005
10Virus Diseases (Viral Diseases)
01/2022 - 02/2003
10Chronic Hepatitis (Chronic Active Hepatitis)
10/2021 - 10/2008
9Adenocarcinoma
08/2021 - 02/2015
9Fatty Liver
07/2021 - 12/2011
9Ulcerative Colitis
01/2021 - 05/2012
9Colonic Neoplasms (Colon Cancer)
08/2019 - 01/2003
9Neoplasm Metastasis (Metastasis)
03/2019 - 03/2007
8Obesity
06/2020 - 01/2008
8Chronic Hepatitis B
01/2016 - 02/2006
7Hepatitis
01/2021 - 01/2007
7Liver Neoplasms (Liver Cancer)
09/2016 - 01/2007
6Disease Progression
02/2022 - 11/2011
6Hepatitis B
01/2021 - 01/2003
6Pancreatic Neoplasms (Pancreatic Cancer)
01/2020 - 12/2013
6Anemia
08/2019 - 09/2006
5Colorectal Neoplasms (Colorectal Cancer)
03/2022 - 08/2007
5Stomach Neoplasms (Stomach Cancer)
11/2019 - 11/2013
4Esophageal Neoplasms (Esophageal Cancer)
03/2019 - 12/2014

Drug/Important Bio-Agent (IBA)

40InterferonsIBA
10/2020 - 07/2004
40Ribavirin (Virazole)FDA LinkGeneric
08/2019 - 07/2004
31Antiviral Agents (Antivirals)IBA
10/2022 - 01/2006
25Proteins (Proteins, Gene)FDA Link
01/2022 - 01/2003
23Biomarkers (Surrogate Marker)IBA
02/2022 - 02/2012
11SofosbuvirIBA
10/2022 - 11/2014
11RNA (Ribonucleic Acid)IBA
05/2022 - 01/2010
10Pharmaceutical PreparationsIBA
05/2022 - 01/2009
10CytokinesIBA
01/2022 - 08/2006
10Sorafenib (BAY 43-9006)FDA Link
04/2021 - 04/2010
10OligosaccharidesIBA
12/2020 - 05/2012
10micaIBA
10/2019 - 02/2003
9Fetal Proteins (Fetoprotein)IBA
12/2022 - 07/2014
9Glycoproteins (Glycoprotein)IBA
11/2021 - 06/2004
9Lamivudine (Epivir)FDA Link
03/2016 - 05/2008
7DNA (Deoxyribonucleic Acid)IBA
01/2022 - 02/2006
7Dextrans (Dextran)FDA Link
12/2020 - 05/2012
7VaccinesIBA
10/2018 - 01/2006
7Peptides (Polypeptides)IBA
11/2011 - 01/2007
6Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
01/2022 - 03/2007
6Aspartate Aminotransferases (Aspartate Transaminase)IBA
11/2021 - 01/2010
6MicroRNAs (MicroRNA)IBA
01/2021 - 05/2010
6CholesterolIBA
01/2020 - 12/2011
6Small Interfering RNA (siRNA)IBA
07/2017 - 10/2010
6MHC class I-related chain AIBA
06/2010 - 02/2003
5Hepatitis B Surface Antigens (HBsAg)FDA Link
01/2022 - 01/2003
5sodium sulfate (sodium bisulfate)FDA LinkGeneric
12/2020 - 05/2012
5Carrier Proteins (Binding Protein)IBA
06/2020 - 10/2013
5SimeprevirIBA
06/2020 - 08/2014
5sofosbuvir drug combination ledipasvirIBA
05/2020 - 06/2015
5telaprevirIBA
07/2017 - 08/2014
5alpha-1,6-mannosylglycoprotein beta 1,6-N-acetylglucosaminyltransferaseIBA
11/2016 - 06/2012
5NucleotidesIBA
11/2015 - 01/2007
5entecavirFDA Link
07/2015 - 06/2008
5LigandsIBA
04/2015 - 11/2003
5AdiponectinIBA
06/2014 - 01/2008
4velpatasvirIBA
10/2022 - 07/2018
4Bevacizumab (Avastin)FDA Link
07/2022 - 08/2021
4lenvatinibIBA
07/2022 - 11/2019
4Interleukin-6 (Interleukin 6)IBA
02/2022 - 11/2007
4Warfarin (Coumadin)FDA LinkGeneric
01/2022 - 03/2014
4alpha-Fetoproteins (alpha-Fetoprotein)IBA
01/2022 - 07/2015
4Hepatitis B e AntigensIBA
01/2022 - 01/2010
4Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
08/2021 - 08/2007
4EnzymesIBA
05/2021 - 04/2016
4ledipasvirIBA
01/2021 - 06/2015
4Leucine (L-Leucine)FDA Link
01/2021 - 11/2012
4Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
01/2021 - 01/2006
4BilirubinIBA
09/2020 - 10/2009
4Hemoglobins (Hemoglobin)IBA
08/2020 - 09/2006
4Transcription Factors (Transcription Factor)IBA
01/2020 - 12/2012
4Biological ProductsIBA
11/2018 - 06/2012
4Pentetic Acid (DTPA)FDA LinkGeneric
11/2017 - 01/2015
4gadolinium ethoxybenzyl DTPAFDA Link
11/2017 - 01/2015
4GadoliniumIBA
11/2017 - 01/2015
4Sulfonic AcidsIBA
08/2017 - 05/2012
4Heparin (Liquaemin)FDA LinkGeneric
12/2016 - 01/2013
4GlycosyltransferasesIBA
11/2016 - 06/2012
4AntigensIBA
03/2016 - 12/2008
4Alanine Transaminase (SGPT)IBA
06/2014 - 12/2010

Therapy/Procedure

78Therapeutics
03/2022 - 07/2004
13Drug Therapy (Chemotherapy)
07/2022 - 08/2007
7Radiofrequency Ablation
12/2022 - 07/2010
5Chemoradiotherapy
03/2019 - 09/2014
4Immunotherapy
05/2022 - 10/2007
4Radiotherapy
01/2022 - 06/2012
4Ligation
04/2015 - 11/2007